WASHINGTON, August 25, 2014 (AFP) – Mice that were raised in a sterile environment or given antibiotics early in life lacked a common gut bacteria that appears to prevent food allergies, US researchers said Monday.
The bacterium, called Clostridia, appears to minimize the likelihood that rodents will become allergic to peanuts, and researchers would like to find out if it does the same in people.
In the meantime, they found that supplementing rodents with probiotics containing Clostridia later in life could reverse the allergy, according to the report in the Proceedings of the National Academy of Sciences.
“Environmental stimuli such as antibiotic overuse, high-fat diets, caesarean birth, removal of common pathogens and even formula feeding have affected the microbiota with which we’ve co-evolved,” said senior study author Cathryn Nagler, food allergy professor at the University of Chicago.
“Our results suggest this could contribute to the increasing susceptibility to food allergies.”
Researchers say the incidence of food allergies among children in the United States rose 18 percent from 1997 to 2007.
The precise cause of food allergies is unknown, but some studies suggest that changes in diet, hygiene and use of antimicrobial soap and disinfecting products may lead to changes in the bacteria of the gastrointestinal tract that leave people more susceptible.[pq]Some food allergies can be fatal.[/pq]
Researchers experimented on mice, exposing some mice born and raised in sterile conditions to peanut allergens. They also tested mice given antibiotics as newborns, a practice which significantly reduced gut bacteria.
Both groups of mice showed significantly higher levels of antibody response against peanut allergens than did regular mice with average gut bacteria.
Their sensitization to food allergens could be reversed if Clostridia bacteria were introduced back into the guts of the mice.
“It’s exciting because we know what the bacteria are; we have a way to intervene,” Nagler said.
“There are of course no guarantees, but this is absolutely testable as a therapeutic against a disease for which there’s nothing.”
More research is needed to see if the effect would be the same in humans, she said.
– AFP News