It seems logical that replacing sugar with a non-calorie containing substitute will improve blood glucose level. In theory, it can help prevent diabetes mellitus and improve glucose control among those who are already diabetic.
The American Dietetic Association in a 2010 review concluded that, in general, artificial sweeteners do not affect glycemic response in people with diabetes mellitus.
A study examined the relationship between intake of sugar-sweetened beverages and artificially-sweetened beverages and the development of type 2 diabetes mellitus. They followed healthy men for duration of 20 years.
They noted that artificially-sweetened beverages intake was significantly associated with developing type 2 diabetes mellitus in an age-adjusted analysis.
There are a few trials that examined glycemic response (plasma glucose and insulin, HbA1c, C-peptide) to artificial sweeteners. These studies found no significant difference between the effects of artificial sweetener and sugar and, in general, did not detect clinically relevant effects.[pq]Studies found no significant difference between the glycemic effects of artificial sweetener and sugar.[/pq]
Furthermore, there are observational studies showing an association of chronic ingestion of artificial sweeteners and occurrence of diabetes mellitus.
– Dr. Allan Dampil